Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | FPR2 | P25090 | 3/20 | 0.37 |
| ▸ | PROKR1 | Q8TCW9 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL696114 | 0.91 | DRD2 (0.38) | KMT2AMEN1EPHX2FPR2PROKR1 | |
| SCHEMBL695528 | 0.88 | CCR4 (0.36) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL3724272 | 0.86 | FKBP1A (0.37) | KMT2AEPHX2ALDH1A1 | |
| SCHEMBL3721306 | 0.85 | CTSS (0.34) | KMT2AALDH1A1 | |
| SCHEMBL694457 | 0.82 | AADAT (0.36) | MAPT | |
| SCHEMBL696136 | 0.81 | AADAT (0.39) | MAPTSMN1; SMN2 | |
| SCHEMBL696150 | 0.80 | FKBP1A (0.40) | ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL690481 | 0.79 | TSHR (0.36) | KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL3719340 | 0.78 | RAB9A (0.37) | KMT2AMEN1LMNA | |
| SCHEMBL695727 | 0.78 | CHRM1 (0.35) | LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421826-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010121918-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-28 | — | — | WO | disclosed |