Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.36 |
| ▸ | CCR4 | P51679 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL695528 | 0.90 | CCR4 (0.36) | RAB9ACCR4MEN1KMT2AKEAP1 | |
| SCHEMBL3724272 | 0.85 | FKBP1A (0.37) | KMT2A | |
| SCHEMBL696150 | 0.82 | FKBP1A (0.40) | RAB9ACCR4 | |
| SCHEMBL695772 | 0.82 | ALDH1A1 (0.41) | RAB9ALMNAKEAP1 | |
| SCHEMBL694889 | 0.82 | P2RX7 (0.40) | P2RX7KMT2ARORCHSD11B1 | |
| SCHEMBL3725935 | 0.79 | P2RX7 (0.43) | P2RX7KMT2ARORCHSD11B1 | |
| SCHEMBL696054 | 0.79 | ACE (0.37) | RAB9ALMNAKEAP1 | |
| SCHEMBL696225 | 0.78 | KMT2A (0.37) | MEN1KMT2ALMNA | |
| SCHEMBL3721306 | 0.75 | CTSS (0.34) | KMT2ARORCKEAP1HSD11B1 | |
| SCHEMBL695637 | 0.74 | FKBP1A (0.42) | RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010121918-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-28 | — | — | WO | disclosed |