Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 11/20 | 0.37 |
| ▸ | DRD3 | P35462 | 4/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | HTR4 | Q13639 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8307501 | 0.86 | GPR55 (0.39) | DRD4KMT2A | |
| SCHEMBL6961633 | 0.85 | HTR4 (0.47) | HTR4KMT2AMEN1ALDH1A1CYP2D6 | |
| Bromide SCHEMBL7744560 | 0.84 | HTR4 (0.46) | HTR4KMT2AMEN1ALDH1A1CYP2D6 | |
| SCHEMBL8310238 | 0.83 | DRD4 (0.48) | DRD4DRD3DRD2KMT2AMEN1 | |
| SCHEMBL7799610 | 0.81 | HTR4 (0.38) | HTR4KMT2AMEN1ALDH1A1CYP2D6 | |
| SCHEMBL8308838 | 0.81 | DRD4 (0.38) | DRD4HTR4ALDH1A1TSHR | |
| SCHEMBL7799616 | 0.79 | HTR4 (0.36) | DRD4HTR4KMT2AMEN1ALDH1A1 | |
| SCHEMBL6958303 | 0.79 | DRD4 (0.41) | DRD4ALDH1A1TSHR | |
| SCHEMBL8305942 | 0.79 | TP53 (0.40) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL8309066 | 0.76 | HTR4 (0.46) | DRD3HTR4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0980368-B1 | 3-(PYRROLIDIN-3-YL)-1,3,4-OXADIAZOL-2(3H)-ONE DERIVATIVES AND THEIR USE AS 5-HT4 LIGANDS | SANOFI SYNTHELABO (FR) | 2003-10-22 | — | — | EP | disclosed |
| US-6248757-B1 | ANTISEROTONINE AGENTS | SANOFI-SYNTHELABO (FR) | 2001-06-19 | — | — | US | disclosed |