Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | PAICS | P22234 | 2/20 | 0.35 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.35 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MELK | Q14680 | 1/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.33 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | HCK | P08631 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308838 | 0.95 | DRD4 (0.38) | DRD4PAICSSUV39H2STAT3ALDH1A1 | |
| SCHEMBL7799616 | 0.86 | HTR4 (0.36) | DRD4STAT3ALDH1A1TDP1HPGD | |
| SCHEMBL8307501 | 0.85 | GPR55 (0.39) | DRD4GPR55CNR1 | |
| SCHEMBL7799610 | 0.85 | HTR4 (0.38) | STAT3ALDH1A1HPGDGPR55 | |
| Hydrochloric Acid SCHEMBL7943941 | 0.84 | HTR4 (0.37) | TDP1GPR55 | |
| SCHEMBL7750256 | 0.83 | SUV39H2 (0.35) | S1PR2SUV39H2HPGDMELKPIK3CD | |
| SCHEMBL8305942 | 0.82 | TP53 (0.40) | SUV39H2ALDH1A1GPR55CNR1 | |
| SCHEMBL8368080 | 0.81 | FAAH (0.43) | DRD4ALDH1A1SRCKDRCNR1 | |
| SCHEMBL6967209 | 0.79 | DRD4 (0.37) | DRD4ALDH1A1TSHR | |
| SCHEMBL8310238 | 0.79 | DRD4 (0.48) | DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0980368-B1 | 3-(PYRROLIDIN-3-YL)-1,3,4-OXADIAZOL-2(3H)-ONE DERIVATIVES AND THEIR USE AS 5-HT4 LIGANDS | SANOFI SYNTHELABO (FR) | 2003-10-22 | — | — | EP | disclosed |
| US-6248757-B1 | ANTISEROTONINE AGENTS | SANOFI-SYNTHELABO (FR) | 2001-06-19 | — | — | US | disclosed |