Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.38 |
| ▸ | CHRNG | P07510 | 1/20 | 0.38 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | CHRND | Q07001 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6971971 | 0.87 | NPC1 (0.44) | OPRM1OPRL1MAPTRAB9ANPC1 | |
| SCHEMBL6981777 | 0.86 | AKR1C1 (0.41) | OPRM1OPRL1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL6981106 | 0.84 | APP (0.43) | OPRM1OPRL1MAPTKMT2AL3MBTL1 | |
| SCHEMBL6978477 | 0.84 | LMNA (0.39) | OPRM1OPRL1RAB9ANPC1KMT2A | |
| SCHEMBL6982594 | 0.81 | HSD11B1 (0.39) | RAB9ANPC1KMT2ACHRNA1CHRNG | |
| SCHEMBL6967893 | 0.81 | CNR1 (0.40) | MAPTKMT2AMAPK1CES2CES1 | |
| SCHEMBL20091128 | 0.79 | CES2 (0.51) | OPRM1OPRL1MAPTRAB9ANPC1 | |
| SCHEMBL6981080 | 0.77 | THRB (0.44) | OPRM1OPRL1RAB9ANPC1CES2 | |
| SCHEMBL20091138 | 0.76 | CES2 (0.55) | OPRM1OPRL1MAPTRAB9ANPC1 | |
| SCHEMBL6984599 | 0.76 | RXRA (0.53) | RAB9ANPC1ALDH1A1SMN1; SMN2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098893-B1 | CYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PROCESS | MERCK PATENT GMBH (DE) | 2003-03-26 | — | — | EP | disclosed |