Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6981777 | 0.90 | AKR1C1 (0.41) | LMNAOPRM1OPRL1L3MBTL1AKR1C1 | |
| SCHEMBL6967893 | 0.84 | CNR1 (0.40) | CES2CES1L3MBTL1AKR1C1KMT2A | |
| SCHEMBL6982594 | 0.84 | HSD11B1 (0.39) | CYP2C19AKR1C1SMN1; SMN2CHRNB2SLC6A2 | |
| SCHEMBL6971207 | 0.84 | OPRM1 (0.44) | OPRM1OPRL1CES2CES1L3MBTL1 | |
| SCHEMBL6979724 | 0.83 | OPRM1 (0.45) | LMNAOPRM1OPRK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL6981080 | 0.81 | THRB (0.44) | LMNAOPRM1OPRL1OPRK1CES2 | |
| SCHEMBL377756 | 0.79 | MAPK1 (0.40) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL6973280 | 0.78 | SLC6A2 (0.37) | CYP2C19SMN1; SMN2CHRNB2SLC6A2CHRNB4 | |
| SCHEMBL7823214 | 0.77 | KIF11 (0.36) | LMNA | |
| SCHEMBL6984599 | 0.76 | RXRA (0.53) | LMNACYP2C19CYP1A2SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098893-B1 | CYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PROCESS | MERCK PATENT GMBH (DE) | 2003-03-26 | — | — | EP | disclosed |