Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CPA1 | P15085 | 3/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27375412 | 0.87 | LTB4R (0.40) | KDM4EALDH1A1LMNA | |
| SCHEMBL9548337 | 0.84 | CPA3 (0.56) | CPA1 | |
| SCHEMBL10370914 | 0.79 | TSHR (0.50) | KDM4EALDH1A1LMNACA12CA7 | |
| SCHEMBL7933675 | 0.78 | ALDH1A1 (0.50) | KDM4EALDH1A1LMNACA12CA7 | |
| SCHEMBL23552019 | 0.78 | ALDH1A1 (0.50) | KDM4EALDH1A1LMNACA12CA7 | |
| SCHEMBL9356423 | 0.78 | CPA1 (0.44) | CPA1NPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL3024154 | 0.78 | CA12 (0.44) | KDM4EALDH1A1LMNACA12CA7 | |
| SCHEMBL23551868 | 0.77 | MMP2 (0.51) | KDM4EALDH1A1LMNACA12CA7 | |
| SCHEMBL1915234 | 0.77 | CPA3 (0.68) | CPA1 | |
| SCHEMBL1915616 | 0.77 | CPA3 (0.68) | CPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821674-B1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2003-08-06 | — | — | EP | disclosed |
| CN-1058261-C | Synthesis of 3, 4, 5 mono-or polysubstituted pyrrolidone-2 compounds | KUNMING PLANT INST CHINESE ACA (CN) | 2000-11-08 | — | — | CN | disclosed |
| US-6043261-A | TREATMENT OF INFLAMMATORY CONDITIONS AFFECTING THE JOINTS, FOR EXAMPLE ARTHRITIS, INFLAMMATORY BOWEL DISEASE, CARDIOVASCULAR ISCHEMIA, DIABETES, HYPERALGESIA, CEREBRAL ISCHEMIA, THROMBOTIC STROKE, GLOBAL ISCHEMIA, NERVOUS SYSTEM DISORDERS | G. D. SEARLE & CO. (US) | 2000-03-28 | — | — | US | disclosed |
| US-5883251-A | ENZYME INHIBITORS | G. D. SEARLE & CO. (US) | 1999-03-16 | — | — | US | disclosed |
| CN-1186071-A | Synthesis of 3, 4, 5 mono-or polysubstituted pyrrolidone-2 compounds | KUNMING PLANT INST CHINESE ACA (CN) | 1998-07-01 | — | — | CN | disclosed |
| EP-0821674-A1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-02-04 | — | — | EP | disclosed |
| WO-1996033175-A1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-10-24 | — | — | WO | disclosed |