Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR3 | Q99500 | 12/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7078713 | 0.93 | S1PR3 (0.39) | S1PR3GRM5PLA2G2AENPP2 | |
| SCHEMBL6961563 | 0.93 | S1PR3 (0.37) | S1PR3GRM5PLA2G2ATLR7 | |
| SCHEMBL6973461 | 0.92 | S1PR3 (0.39) | S1PR3GRM5ENPP2SYKKDM4E | |
| SCHEMBL6972492 | 0.91 | S1PR3 (0.38) | S1PR3PLA2G2AKDM4EALDH1A1LMNA | |
| SCHEMBL7082317 | 0.90 | PLA2G2A (0.36) | S1PR3PLA2G2ATLR7KDM4EALDH1A1 | |
| SCHEMBL6967024 | 0.90 | ALDH1A1 (0.35) | PLA2G2ATLR7KDM4EALDH1A1LMNA | |
| SCHEMBL6972895 | 0.90 | S1PR3 (0.37) | S1PR3PLA2G2ATLR7KDM4EALDH1A1 | |
| SCHEMBL7084180 | 0.90 | S1PR3 (0.39) | S1PR3ENPP2LMNA | |
| SCHEMBL6966022 | 0.90 | ADRA1D (0.36) | S1PR3GRM5PLA2G2ATLR7KDM4E | |
| SCHEMBL6975183 | 0.87 | ENPP2 (0.35) | PLA2G2AENPP2TLR7KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |