Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6960825 | 0.91 | ALDH1A1 (0.32) | ALDH1A1POLBMAPK1 | |
| SCHEMBL6967565 | 0.90 | LMNA (0.32) | ALDH1A1POLBMAPK1LMNASMN1; SMN2 | |
| SCHEMBL7083579 | 0.89 | ALDH1A1 (0.32) | ALDH1A1POLBMAPK1EPHX1 | |
| SCHEMBL6975183 | 0.88 | ENPP2 (0.35) | ALDH1A1POLBLMNASMN1; SMN2NPSR1 | |
| SCHEMBL6968520 | 0.87 | RAB9A (0.35) | LMNAHTTSMN1; SMN2 | |
| SCHEMBL6969053 | 0.86 | TNF (0.32) | LMNAHTTSMN1; SMN2 | |
| SCHEMBL6973048 | 0.85 | ENPP2 (0.35) | ALDH1A1LMNASMN1; SMN2NPSR1 | |
| SCHEMBL7084640 | 0.85 | S1PR3 (0.39) | ALDH1A1LMNA | |
| SCHEMBL6967408 | 0.85 | F10 (0.33) | POLBLMNAHTT | |
| SCHEMBL6965285 | 0.84 | GCGR (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |