Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 5/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8342977 | 0.91 | LMNA (0.45) | ENPP2HDAC6HDAC1HDAC8LMNA | |
| SCHEMBL6969581 | 0.90 | ENPP2 (0.37) | CYP11B1CYP11B2ENPP2LMNATBXAS1 | |
| SCHEMBL6968344 | 0.90 | ALDH1A1 (0.41) | CYP11B1CYP11B2ENPP2KDM4EKMT2A | |
| SCHEMBL6968962 | 0.90 | CYP11B1 (0.41) | CYP11B1CYP11B2ENPP2KDM4EKMT2A | |
| SCHEMBL6970047 | 0.87 | POLB (0.39) | KMT2AHTTSMN1; SMN2MEN1GAA | |
| SCHEMBL7081149 | 0.86 | TLR7 (0.39) | ENPP2HDAC1HDAC8KDM4EHTT | |
| SCHEMBL7084562 | 0.85 | KDM4E (0.37) | ENPP2HDAC1HDAC8KDM4EKMT2A | |
| SCHEMBL6974469 | 0.85 | TLR7 (0.36) | ENPP2HDAC1HDAC8KDM4EKMT2A | |
| SCHEMBL6971326 | 0.84 | HTT (0.41) | KDM4EKMT2AHTTSMN1; SMN2LMNA | |
| SCHEMBL7080963 | 0.84 | TLR7 (0.41) | CYP11B1CYP11B2ENPP2HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |