Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6971258 | 0.95 | LMNA (0.40) | TLR7HDAC1HDAC8L3MBTL1S1PR3 | |
| SCHEMBL6960297 | 0.92 | MDM2 (0.34) | TLR7HDAC1HDAC8L3MBTL1S1PR3 | |
| SCHEMBL7084562 | 0.92 | KDM4E (0.37) | TLR7HDAC1HDAC8L3MBTL1S1PR3 | |
| SCHEMBL7086385 | 0.91 | TLR7 (0.35) | TLR7L3MBTL1S1PR3LMNAHTT | |
| SCHEMBL6973955 | 0.91 | ALDH1A1 (0.35) | TLR7HDAC1HDAC8S1PR3LMNA | |
| SCHEMBL7080841 | 0.90 | GRIN1 (0.36) | S1PR3LMNAKMT2AENPP2ALDH1A1 | |
| SCHEMBL6973316 | 0.90 | ALDH1A1 (0.39) | LMNAKMT2ASMN1; SMN2ALDH1A1GABRA1 | |
| SCHEMBL6968774 | 0.90 | PIM1 (0.35) | TLR7LMNAKMT2AENPP2HIF1A | |
| SCHEMBL6966178 | 0.90 | ADRA1D (0.36) | S1PR3KMT2AALDH1A1GABRA1GABRA5 | |
| SCHEMBL6974966 | 0.90 | GRIN1 (0.36) | TLR7HDAC1HDAC8S1PR3ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |