Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | TOP2A | P11388 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6973782 | 0.96 | TBK1 (0.36) | RAB9ACHEK2TOP2AOPRK1ALDH1A1 | |
| SCHEMBL6979960 | 0.94 | CHEK2 (0.41) | CHEK2TOP2AKMT2ATBK1 | |
| SCHEMBL6972610 | 0.90 | PDE4D (0.41) | TOP2AALDH1A1MEN1KMT2ATBK1 | |
| SCHEMBL6969085 | 0.80 | CHRM3 (0.37) | RAB9AALDH1A1TSHRSMN1; SMN2MEN1 | |
| SCHEMBL6975780 | 0.76 | TBK1 (0.43) | RAB9ACHEK2OPRK1ALDH1A1TSHR | |
| SCHEMBL6476766 | 0.76 | OPRK1 (0.59) | OPRK1ALDH1A1TSHR | |
| SCHEMBL2972096 | 0.75 | OPRK1 (0.58) | OPRK1 | |
| SCHEMBL7804552 | 0.74 | OPRK1 (0.54) | RAB9AOPRK1ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL6975779 | 0.73 | MAPK14 (0.58) | — | |
| SCHEMBL6477083 | 0.72 | MAPK14 (0.54) | OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115707-B1 | BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2003-11-12 | — | — | EP | disclosed |