Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 2/20 | 0.41 |
| ▸ | TOP2A | P11388 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6975773 | 0.94 | RAB9A (0.38) | CHEK2TOP2ATBK1KMT2A | |
| SCHEMBL6972610 | 0.91 | PDE4D (0.41) | TOP2ATBK1KMT2A | |
| SCHEMBL6973782 | 0.90 | TBK1 (0.36) | CHEK2TOP2ATBK1KMT2A | |
| SCHEMBL6979964 | 0.74 | CHEK2 (0.46) | CHEK2TOP2AGPR119TBK1 | |
| SCHEMBL6476511 | 0.72 | MAPK14 (0.62) | GPR119 | |
| SCHEMBL7809442 | 0.72 | MAPK14 (0.52) | GPR119KMT2A | |
| SCHEMBL6979962 | 0.71 | MAPK14 (0.61) | — | |
| SCHEMBL2972096 | 0.69 | OPRK1 (0.58) | GPR119 | |
| SCHEMBL6975780 | 0.69 | TBK1 (0.43) | CHEK2TBK1 | |
| SCHEMBL6476766 | 0.68 | OPRK1 (0.59) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115707-B1 | BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2003-11-12 | — | — | EP | disclosed |