Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | TOP2A | P11388 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6975773 | 0.96 | RAB9A (0.38) | TBK1RAB9AALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL6979960 | 0.90 | CHEK2 (0.41) | TBK1CHEK2TOP2AKMT2A | |
| SCHEMBL6972610 | 0.86 | PDE4D (0.41) | TBK1ALDH1A1TOP2AMEN1KMT2A | |
| SCHEMBL6969085 | 0.79 | CHRM3 (0.37) | RAB9AALDH1A1TSHRSMN1; SMN2MEN1 | |
| SCHEMBL6973788 | 0.76 | TBK1 (0.44) | TBK1ALDH1A1TSHRSMN1; SMN2CHEK2 | |
| SCHEMBL6533594 | 0.76 | OPRK1 (0.56) | ALDH1A1TSHRUSP30OPRK1RAF1 | |
| SCHEMBL2979241 | 0.76 | OPRK1 (0.55) | ALDH1A1TSHRUSP30OPRK1RAF1 | |
| SCHEMBL7806472 | 0.75 | OPRK1 (0.51) | TBK1ALDH1A1TSHRUSP30SMN1; SMN2 | |
| SCHEMBL6973786 | 0.74 | MAPK14 (0.57) | RAF1BRAF | |
| SCHEMBL6975780 | 0.72 | TBK1 (0.43) | TBK1RAB9AALDH1A1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115707-B1 | BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2003-11-12 | — | — | EP | disclosed |