Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 12/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 12/20 | 0.43 |
| ▸ | CACNB1 | Q02641 | 12/20 | 0.43 |
| ▸ | CACNA1C | Q13936 | 10/20 | 0.43 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6983244 | 0.91 | CACNA1B (0.35) | CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL6971808 | 0.89 | HTR7 (0.40) | CACNA1CCACNA1G | |
| SCHEMBL6975992 | 0.88 | TSHR (0.44) | GAATSHR | |
| SCHEMBL6976114 | 0.85 | USP2 (0.32) | TDP1GAATSHR | |
| SCHEMBL6974100 | 0.83 | NPC1 (0.48) | CACNA1CTSHR | |
| Hydrochloric Acid SCHEMBL6984860 | 0.82 | OPRL1 (0.37) | — | |
| SCHEMBL9698183 | 0.82 | OPRM1 (0.38) | GAA | |
| Hydrochloric Acid SCHEMBL8713715 | 0.81 | MEN1 (0.38) | GAA | |
| Hydrochloric Acid SCHEMBL6982801 | 0.81 | SIGMAR1 (0.41) | — | |
| SCHEMBL6975786 | 0.80 | POLB (0.40) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923575-B1 | CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-03-12 | — | — | EP | disclosed |
| US-6172085-B1 | CENTRAL NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-01-09 | — | — | US | disclosed |