Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 10/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TET3 | O43151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.37 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.37 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.37 |
| ▸ | CXXC4 | Q9H2H0 | 1/20 | 0.37 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL377756 | 0.82 | MAPK1 (0.40) | HSD11B1HDAC4CCR2ALDH1A1MAPK1 | |
| SCHEMBL2671790 | 0.80 | ALDH1A1 (0.41) | HSD11B1HDAC4CCR2ALDH1A1MAPK1 | |
| SCHEMBL6977864 | 0.79 | MEN1 (0.51) | HSD11B1ALDH1A1MAPK1KMT2ALMNA | |
| SCHEMBL6967893 | 0.78 | CNR1 (0.40) | HSD11B1ALDH1A1MAPK1TET3KMT2A | |
| SCHEMBL6971210 | 0.77 | CYP1A2 (0.41) | HSD11B1KMT2ALMNA | |
| SCHEMBL6975695 | 0.76 | POLB (0.38) | HSD11B1ALDH1A1MAPK1KMT2APTGS2 | |
| SCHEMBL6974413 | 0.75 | HRH1 (0.37) | HDAC4MAPK1LMNA | |
| SCHEMBL6982483 | 0.75 | KIF11 (0.44) | HSD11B1HDAC4ALDH1A1MAPK1LMNA | |
| SCHEMBL6975649 | 0.74 | L3MBTL1 (0.42) | ALDH1A1KMT2A | |
| SCHEMBL1794 | 0.71 | AKR1C1 (0.62) | HSD11B1HDAC4ALDH1A1TET3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098893-B1 | CYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PROCESS | MERCK PATENT GMBH (DE) | 2003-03-26 | — | — | EP | disclosed |