Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CCR3 | P51677 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | GPR183 | P32249 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6967893 | 0.80 | CNR1 (0.40) | L3MBTL1MAPTALDH1A1KMT2A | |
| SCHEMBL377756 | 0.77 | MAPK1 (0.40) | ALDH1A1KMT2A | |
| SCHEMBL6971210 | 0.75 | CYP1A2 (0.41) | TDP1MEN1KMT2AMDM2 | |
| SCHEMBL6976918 | 0.74 | HSD11B1 (0.40) | ALDH1A1KMT2A | |
| SCHEMBL6974413 | 0.73 | HRH1 (0.37) | — | |
| SCHEMBL6982483 | 0.73 | KIF11 (0.44) | ALDH1A1 | |
| SCHEMBL2671790 | 0.72 | ALDH1A1 (0.41) | ALDH1A1KMT2A | |
| SCHEMBL6975695 | 0.71 | POLB (0.38) | ALDH1A1MEN1KMT2A | |
| SCHEMBL6981777 | 0.69 | AKR1C1 (0.41) | L3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL7137847 | 0.67 | LMNA (0.42) | MAPTCCR3TDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098893-B1 | CYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PROCESS | MERCK PATENT GMBH (DE) | 2003-03-26 | — | — | EP | disclosed |