Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 5/20 | 0.36 |
| ▸ | DRD2 | P14416 | 4/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6984897 | 0.94 | DRD3 (0.38) | KDM4EMEN1KMT2AMAPTTAAR1 | |
| SCHEMBL6981092 | 0.89 | DRD3 (0.34) | MEN1KMT2ATSHRMAPTLMNA | |
| Hydrochloric Acid SCHEMBL6982794 | 0.88 | KMT2A (0.35) | MEN1KMT2ATSHRMAPTLMNA | |
| Oxalic Acid SCHEMBL6980644 | 0.76 | GRM5 (0.42) | LMNADRD3DRD2HTR1AHTR2A | |
| SCHEMBL6985365 | 0.76 | LMNA (0.42) | ALDH1A1LMNAPOLBDRD4 | |
| SCHEMBL6983488 | 0.76 | DRD2 (0.41) | KDM4EALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL6975992 | 0.76 | TSHR (0.44) | KDM4EALDH1A1MEN1KMT2ATSHR | |
| Hydrochloric Acid SCHEMBL6979044 | 0.75 | LMNA (0.41) | ALDH1A1MEN1KMT2ATSHRMAPT | |
| SCHEMBL6980780 | 0.75 | CACNA2D1 (0.43) | TSHRGAA | |
| SCHEMBL3936672 | 0.75 | HTR1A (0.46) | KDM4EMEN1KMT2AGAAHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923575-B1 | CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-03-12 | — | — | EP | disclosed |
| US-6172085-B1 | CENTRAL NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-01-09 | — | — | US | disclosed |