Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | YAP1 | P46937 | 1/20 | 0.43 |
| ▸ | EDNRB | P24530 | 2/20 | 0.43 |
| ▸ | EDNRA | P25101 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.42 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.40 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7123772 | 0.88 | SMN1; SMN2 (0.51) | ALDH1A1TSHRHSD17B10KMT2AMCHR1 | |
| SCHEMBL6980741 | 0.88 | HPGD (0.47) | ALDH1A1TSHRGFERHSD17B10KMT2A | |
| SCHEMBL6980066 | 0.85 | ALDH1A1 (0.48) | ALDH1A1TSHRHSD17B10KMT2AMEN1 | |
| SCHEMBL6972446 | 0.82 | HSD17B10 (0.48) | ALDH1A1YAP1HSD17B10LMNASMN1; SMN2 | |
| SCHEMBL6976878 | 0.78 | HSD11B1 (0.51) | ALDH1A1KMT2AMEN1LMNAHPGD | |
| SCHEMBL6973351 | 0.76 | DRD2 (0.52) | ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL6976438 | 0.74 | NPC1 (0.45) | KMT2ALMNA | |
| SCHEMBL6975639 | 0.72 | MAP3K12 (0.49) | KMT2AMEN1LMNA | |
| SCHEMBL8392370 | 0.70 | MAOB (0.41) | ALDH1A1EDNRBEDNRAMAOBLMNA | |
| SCHEMBL6981142 | 0.70 | GLA (0.55) | TSHRKMT2AMEN1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892795-B1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMA (JP) | 2003-01-08 | — | — | EP | disclosed |
| EP-0892795-A1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997038992-A1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1997-10-23 | — | — | WO | disclosed |