Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TRPC6 | Q9Y210 | 3/20 | 0.47 |
| ▸ | YAP1 | P46937 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPK7 | Q13164 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6976878 | 0.87 | HSD11B1 (0.51) | RAB9AALDH1A1LMNAHSD11B1HPGD | |
| SCHEMBL6976438 | 0.83 | NPC1 (0.45) | TRPC6NPC1RAB9ALMNAHSD11B1 | |
| SCHEMBL6979916 | 0.82 | ALDH1A1 (0.43) | HSD17B10YAP1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL7123772 | 0.80 | SMN1; SMN2 (0.51) | HSD17B10NPC1RAB9AALDH1A1TP53 | |
| SCHEMBL6981142 | 0.79 | GLA (0.55) | — | |
| SCHEMBL6981137 | 0.78 | SMN1; SMN2 (0.54) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL6972466 | 0.78 | ALDH1A1 (0.44) | TRPC6RAB9AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL12381384 | 0.74 | L3MBTL1 (0.56) | HSD17B10NPC1RAB9AALDH1A1TP53 | |
| SCHEMBL6974760 | 0.74 | MAP3K12 (0.55) | RAB9AALDH1A1SMN1; SMN2LMNAHSD11B1 | |
| SCHEMBL9356201 | 0.73 | HPGD (0.62) | HSD17B10NPC1RAB9AALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892795-B1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMA (JP) | 2003-01-08 | — | — | EP | disclosed |
| US-5948786-A | BLOCKING TUMOR NECROSIS FACTOR | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-09-07 | — | — | US | disclosed |