Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 4/20 | 0.34 |
| ▸ | MMP3 | P08254 | 3/20 | 0.34 |
| ▸ | MMP7 | P09237 | 3/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 2/20 | 0.30 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6983032 | 0.89 | MMP3 (0.34) | ADAM17MMP1MMP3MMP13MMP2 | |
| SCHEMBL6982558 | 0.76 | BMP1 (0.33) | MMP2 | |
| SCHEMBL29114068 | 0.65 | HDAC3 (0.45) | HSPA5 | |
| SCHEMBL6980577 | 0.64 | MMP1 (0.35) | MMP1MMP3MMP7 | |
| SCHEMBL6982654 | 0.64 | MMP1 (0.52) | ADAM17MMP1MMP3MMP7MMP13 | |
| SCHEMBL5161632 | 0.64 | NPC1 (0.42) | HSPA5 | |
| Hydrochloric Acid SCHEMBL6985216 | 0.64 | ADAM17 (0.61) | ADAM17MMP1MMP3MMP7MMP13 | |
| SCHEMBL6986418 | 0.63 | ADAM17 (0.70) | ADAM17MMP1MMP3MMP7MMP13 | |
| SCHEMBL6984793 | 0.63 | MMP1 (0.39) | ADAM17MMP1MMP3MMP7MMP13 | |
| SCHEMBL6937771 | 0.63 | ADAM17 (0.69) | ADAM17MMP1MMP3MMP7MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |