Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 5/20 | 0.34 |
| ▸ | MMP1 | P03956 | 3/20 | 0.34 |
| ▸ | BMP1 | P13497 | 15/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 4/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6980581 | 0.89 | ADAM17 (0.36) | MMP3MMP1ADAM17MMP2MMP13 | |
| SCHEMBL6982558 | 0.86 | BMP1 (0.33) | BMP1APPMMP2 | |
| SCHEMBL6980963 | 0.75 | MMP1 (0.36) | MMP3MMP1BMP1APPADAM17 | |
| SCHEMBL6987397 | 0.71 | BMP1 (0.37) | MMP3MMP1BMP1APPADAM17 | |
| SCHEMBL6942694 | 0.71 | ADAM17 (0.51) | MMP3MMP1BMP1ADAM17MMP2 | |
| SCHEMBL6982620 | 0.70 | BMP1 (0.39) | MMP1BMP1APPADAM17MMP2 | |
| SCHEMBL6987387 | 0.70 | BMP1 (0.36) | MMP3MMP1BMP1APPADAM17 | |
| SCHEMBL6983030 | 0.69 | MMP1 (0.32) | MMP3MMP1MMP2 | |
| SCHEMBL6978346 | 0.68 | REN (0.31) | — | |
| SCHEMBL6989548 | 0.67 | BMP1 (0.35) | MMP3MMP1BMP1APPADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |