Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 7/20 | 0.32 |
| ▸ | MMP1 | P03956 | 5/20 | 0.32 |
| ▸ | MMP8 | P22894 | 5/20 | 0.32 |
| ▸ | MMP3 | P08254 | 4/20 | 0.32 |
| ▸ | MMP9 | P14780 | 4/20 | 0.32 |
| ▸ | MMP13 | P45452 | 2/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 6/20 | 0.32 |
| ▸ | MMP7 | P09237 | 2/20 | 0.32 |
| ▸ | TNF | P01375 | 2/20 | 0.32 |
| ▸ | MMP20 | O60882 | 1/20 | 0.32 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.32 |
| ▸ | MMP10 | P09238 | 1/20 | 0.32 |
| ▸ | MMP12 | P39900 | 1/20 | 0.32 |
| ▸ | MMP14 | P50281 | 1/20 | 0.32 |
| ▸ | MMP15 | P51511 | 1/20 | 0.32 |
| ▸ | MMP16 | P51512 | 1/20 | 0.32 |
| ▸ | MMP25 | Q9NPA2 | 1/20 | 0.32 |
| ▸ | MMP26 | Q9NRE1 | 1/20 | 0.32 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.32 |
| ▸ | MMP24 | Q9Y5R2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6986332 | 0.99 | MMP2 (0.32) | MMP2MMP1MMP8MMP3MMP9 | |
| SCHEMBL6980958 | 0.81 | MMP1 (0.35) | MMP2MMP1MMP8MMP3MMP9 | |
| SCHEMBL6982649 | 0.81 | ANPEP (0.40) | MMP2MMP1MMP8MMP3MMP13 | |
| SCHEMBL6945575 | 0.73 | MMP2 (0.39) | MMP2MMP1MMP8MMP3MMP9 | |
| SCHEMBL6983384 | 0.72 | ADAM17 (0.41) | MMP2MMP1MMP3MMP9ADAM17 | |
| SCHEMBL6981614 | 0.72 | ADAM17 (0.39) | MMP2MMP1MMP8MMP3MMP9 | |
| SCHEMBL6980436 | 0.71 | MMP8 (0.36) | MMP2MMP1MMP8MMP3MMP9 | |
| Hydrochloric Acid SCHEMBL6986445 | 0.71 | ADAM17 (0.39) | MMP2MMP1MMP8MMP3MMP9 | |
| SCHEMBL6983506 | 0.68 | HPGD (0.37) | MMP2MMP1MMP8MMP3MMP9 | |
| SCHEMBL6938049 | 0.68 | ADAM17 (0.35) | MMP2MMP1MMP8MMP3MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |