Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8578232 | 0.94 | SIGMAR1 (0.46) | SIGMAR1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL6979051 | 0.88 | LMNA (0.41) | SIGMAR1MAPTNPSR1DRD2MEN1 | |
| SCHEMBL6983492 | 0.84 | CHRNA7 (0.40) | SIGMAR1MAPTNPSR1HTR1ADRD2 | |
| SCHEMBL6981079 | 0.84 | HRH3 (0.40) | SIGMAR1ACHE | |
| Hydrochloric Acid SCHEMBL6982807 | 0.83 | SIGMAR1 (0.42) | SIGMAR1SLC6A3HTR1ADRD2MEN1 | |
| SCHEMBL6981931 | 0.83 | HRH3 (0.39) | SIGMAR1ACHE | |
| SCHEMBL6979708 | 0.83 | PRMT6 (0.43) | SIGMAR1KCNH2 | |
| Hydrochloric Acid SCHEMBL6985676 | 0.80 | SMN1; SMN2 (0.42) | SIGMAR1MAPTNPSR1SLC6A3MEN1 | |
| SCHEMBL8573871 | 0.80 | LMNA (0.42) | MEN1ALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL6984760 | 0.80 | DRD2 (0.40) | SIGMAR1HTR1ADRD2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923575-B1 | CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-03-12 | — | — | EP | disclosed |
| US-6172085-B1 | CENTRAL NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-01-09 | — | — | US | disclosed |