Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 6/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6981386 | 0.95 | REN (0.38) | RENMMP3CTSSCTSK | |
| SCHEMBL7816193 | 0.85 | CTSS (0.35) | CTSSCTSK | |
| SCHEMBL6981382 | 0.85 | REN (0.32) | RENMMP3 | |
| SCHEMBL7812670 | 0.82 | GPR88 (0.32) | MMP3 | |
| SCHEMBL6982709 | 0.80 | CTSK (0.37) | MMP3CTSSCTSK | |
| SCHEMBL6981703 | 0.79 | MMP3 (0.33) | RENMMP3 | |
| SCHEMBL6980731 | 0.78 | AGTR2 (0.34) | CTSSCTSK | |
| SCHEMBL6986860 | 0.78 | MMP3 (0.35) | RENMMP3CTSSCTSK | |
| SCHEMBL7805709 | 0.77 | GPR88 (0.34) | RENMMP3 | |
| SCHEMBL6978663 | 0.77 | REN (0.36) | RENMMP3TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |