Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | REN | P00797 | 6/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7812670 | 0.95 | GPR88 (0.32) | GPR88MMP3 | |
| SCHEMBL7812254 | 0.89 | PSEN1 (0.35) | GPR88MMP3RENPSEN1PSEN2 | |
| SCHEMBL6981703 | 0.85 | MMP3 (0.33) | MMP3RENPSEN1PSEN2APH1B | |
| SCHEMBL6981386 | 0.83 | REN (0.38) | MMP3REN | |
| SCHEMBL6986123 | 0.81 | CTSS (0.36) | MMP3REN | |
| SCHEMBL7805463 | 0.80 | MEN1 (0.30) | MMP3 | |
| SCHEMBL6982283 | 0.77 | REN (0.36) | MMP3REN | |
| SCHEMBL6983113 | 0.75 | CYP1A2 (0.36) | REN | |
| SCHEMBL6982709 | 0.75 | CTSK (0.37) | MMP3 | |
| SCHEMBL8097980 | 0.74 | GPR88 (0.31) | GPR88 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-A1 | HYDRAZINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000000465-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-01-06 | — | — | WO | disclosed |