Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6988884 | 0.86 | CTSS (0.36) | — | |
| SCHEMBL6987871 | 0.84 | CTSK (0.39) | — | |
| SCHEMBL6753779 | 0.83 | CTSL (0.37) | — | |
| SCHEMBL6982132 | 0.83 | TAOK1 (0.36) | MAPK8 | |
| SCHEMBL6988403 | 0.83 | KMT2A (0.35) | — | |
| SCHEMBL6989542 | 0.83 | TP53 (0.40) | — | |
| SCHEMBL6990082 | 0.82 | MAPT (0.41) | — | |
| SCHEMBL6990056 | 0.82 | OPRM1 (0.37) | — | |
| SCHEMBL6988433 | 0.81 | TAS1R3 (0.35) | — | |
| SCHEMBL6988694 | 0.80 | ATM (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362042-A1 | CYCLIC 2-CARBONYLAMINOKETONES AS INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002057249-A1 | CYCLIC 2-CARBONYLAMINOKETONES AS INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |