Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP5 | P51878 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KHK | P50053 | 1/20 | 0.38 |
| ▸ | SMO | Q99835 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6981026 | 0.89 | AGTR2 (0.40) | MGLLTSHRALDH1A1MAPTLMNA | |
| SCHEMBL6984622 | 0.87 | AGTR2 (0.39) | MGLLCASP1TSHRALDH1A1LMNA | |
| SCHEMBL6986283 | 0.85 | HTR2C (0.42) | DRD2KHKAGTR2 | |
| SCHEMBL6988437 | 0.84 | ALDH1A1 (0.45) | TSHRALDH1A1LMNANPC1RAB9A | |
| SCHEMBL6981802 | 0.83 | ALDH1A1 (0.42) | TSHRALDH1A1MAPTNPSR1LMNA | |
| SCHEMBL6986113 | 0.83 | AGTR2 (0.41) | MGLLALDH1A1LMNAUSP2HSD17B10 | |
| SCHEMBL6986237 | 0.82 | AGTR2 (0.39) | ALDH1A1MAPTNPSR1LMNAKDM4E | |
| SCHEMBL6988584 | 0.82 | USP2 (0.43) | MGLLTSHRALDH1A1MAPTLMNA | |
| SCHEMBL6983724 | 0.81 | MEN1 (0.39) | TSHRMAPTLMNAKDM4EUSP2 | |
| SCHEMBL6984642 | 0.80 | HRH3 (0.39) | AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313733-A1 | PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002018382-A1 | PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-03-07 | — | — | WO | disclosed |