Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 1/20 | 0.39 |
| ▸ | KHK | P50053 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.37 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.37 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6981026 | 0.93 | AGTR2 (0.40) | AGTR2KHKKMT2ALMNASMN1; SMN2 | |
| SCHEMBL6986283 | 0.89 | HTR2C (0.42) | AGTR2KHKHTR3AHTR6 | |
| SCHEMBL6988437 | 0.88 | ALDH1A1 (0.45) | KMT2ALMNASMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL6981802 | 0.88 | ALDH1A1 (0.42) | AGTR2KMT2ALMNAPOLBSMN1; SMN2 | |
| SCHEMBL6986113 | 0.88 | AGTR2 (0.41) | AGTR2KMT2ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL6983767 | 0.87 | DRD4 (0.41) | AGTR2KHKKMT2ALMNAPOLB | |
| SCHEMBL6986237 | 0.86 | AGTR2 (0.39) | AGTR2KMT2ALMNAPOLBALDH1A1 | |
| SCHEMBL6984282 | 0.86 | HSD17B10 (0.43) | KMT2ALMNASMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL6988584 | 0.86 | USP2 (0.43) | AGTR2KHKKMT2ALMNAPOLB | |
| SCHEMBL6984642 | 0.85 | HRH3 (0.39) | AGTR2BRD4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313733-A1 | PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002018382-A1 | PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-03-07 | — | — | WO | disclosed |