Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 9/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6985419 | 0.88 | KMT2A (0.41) | KMT2AMEN1ALDH1A1POLBTDP1 | |
| SCHEMBL6984916 | 0.88 | KMT2A (0.41) | KMT2AMEN1ALDH1A1POLBTDP1 | |
| SCHEMBL6172884 | 0.81 | LMNA (0.30) | LMNASMN1; SMN2 | |
| SCHEMBL6173400 | 0.81 | ACHE (0.31) | LMNASMN1; SMN2 | |
| SCHEMBL6986506 | 0.80 | SMN1; SMN2 (0.37) | SMN1; SMN2MAPTKMT2AALDH1A1HTT | |
| SCHEMBL6172320 | 0.79 | SMN1; SMN2 (0.33) | LMNASMN1; SMN2MAPTKMT2AMEN1 | |
| SCHEMBL6982440 | 0.79 | PDK1 (0.41) | LMNASMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL6173064 | 0.78 | CCR2 (0.33) | KMT2AALDH1A1POLBTDP1 | |
| SCHEMBL7088516 | 0.78 | GPR119 (0.45) | — | |
| SCHEMBL6174487 | 0.78 | GPR119 (0.30) | LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289965-B1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2005-10-26 | — | — | EP | disclosed |