Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 11/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GHSR | Q92847 | 1/20 | 0.30 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7085949 | 0.85 | PDK1 (0.35) | CCR2PDK1PDK2PDK3PDK4 | |
| SCHEMBL6985419 | 0.84 | KMT2A (0.41) | PDK1PDK2PDK3PDK4POLB | |
| SCHEMBL6984916 | 0.84 | KMT2A (0.41) | PDK1PDK2PDK3PDK4POLB | |
| SCHEMBL7086025 | 0.80 | CCR2 (0.31) | CCR2 | |
| SCHEMBL6986506 | 0.79 | SMN1; SMN2 (0.37) | CCR2POLBKMT2ATDP1MMP1 | |
| SCHEMBL6173963 | 0.78 | LMNA (0.39) | POLBKMT2ATDP1ALDH1A1 | |
| SCHEMBL6982440 | 0.78 | PDK1 (0.41) | PDK1PDK2PDK3PDK4POLB | |
| SCHEMBL6172702 | 0.78 | PLA2G2A (0.33) | MMP1MMP9MMP13PLA2G2A | |
| SCHEMBL7088516 | 0.78 | GPR119 (0.45) | — | |
| SCHEMBL6172884 | 0.77 | LMNA (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289965-B1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2005-10-26 | — | — | EP | disclosed |