Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | CCR3 | P51677 | 6/20 | 0.48 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.48 |
| ▸ | FPR3 | P25089 | 1/20 | 0.46 |
| ▸ | FPR2 | P25090 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6987557 | 0.90 | HTR1A (0.52) | CCR3HTR7HRH3CACNA1G | |
| Hydrochloric Acid SCHEMBL5842086 | 0.89 | HTR1A (0.53) | CCR3HTR7HRH3SMN1; SMN2CACNA1G | |
| SCHEMBL6987296 | 0.89 | ALDH1A1 (0.54) | LMNAMCHR1CACNA1G | |
| SCHEMBL6981732 | 0.86 | MEN1 (0.54) | LMNAHRH3CYP2D6 | |
| SCHEMBL5840932 | 0.86 | CACNA1G (0.60) | LMNACACNA1G | |
| SCHEMBL6986958 | 0.86 | SMN1; SMN2 (0.54) | CCR2KCNH2FPR3FPR2HTR7 | |
| SCHEMBL6978967 | 0.86 | LMNA (0.53) | LMNACACNA1G | |
| Hydrochloric Acid SCHEMBL5842390 | 0.85 | MEN1 (0.56) | LMNAHRH3CYP2D6SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5842633 | 0.85 | SMN1; SMN2 (0.56) | CCR2KCNH2FPR3FPR2HTR7 | |
| Hydrochloric Acid SCHEMBL5842876 | 0.85 | KMT2A (0.55) | LMNACACNA1G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275647-B1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-11-12 | — | — | EP | disclosed |
| EP-1275647-A1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |