Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | CACNA1G | O43497 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5840932 | 0.89 | CACNA1G (0.60) | CACNA1GLMNAGAASIGMAR1 | |
| SCHEMBL6981732 | 0.89 | MEN1 (0.54) | ALDH1A1LMNASIGMAR1 | |
| SCHEMBL6986958 | 0.89 | SMN1; SMN2 (0.54) | ALDH1A1CACNA1GLMNAGAAKDM4E | |
| SCHEMBL6978967 | 0.89 | LMNA (0.53) | ALDH1A1CACNA1GLMNASIGMAR1 | |
| SCHEMBL6985625 | 0.89 | CCR2 (0.48) | CACNA1GLMNAMCHR1 | |
| Hydrochloric Acid SCHEMBL5842633 | 0.88 | SMN1; SMN2 (0.56) | ALDH1A1CACNA1GLMNAGAAKDM4E | |
| Hydrochloric Acid SCHEMBL5842390 | 0.88 | MEN1 (0.56) | ALDH1A1LMNAGAASIGMAR1 | |
| Hydrochloric Acid SCHEMBL5842876 | 0.88 | KMT2A (0.55) | ALDH1A1CACNA1GLMNAKDM4EATM | |
| SCHEMBL6987557 | 0.86 | HTR1A (0.52) | ALDH1A1CACNA1GSIGMAR1 | |
| SCHEMBL6980711 | 0.86 | MAPT (0.57) | ALDH1A1CACNA1GKDM4EHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275647-B1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-11-12 | — | — | EP | disclosed |
| EP-1275647-A1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |