Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | FPR3 | P25089 | 1/20 | 0.47 |
| ▸ | FPR2 | P25090 | 1/20 | 0.47 |
| ▸ | CCR2 | P41597 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5842633 | 0.99 | SMN1; SMN2 (0.56) | SMN1; SMN2GAATP53L3MBTL1KDM4E | |
| SCHEMBL6987296 | 0.89 | ALDH1A1 (0.54) | GAAKDM4ELMNAALDH1A1CACNA1G | |
| SCHEMBL5840932 | 0.89 | CACNA1G (0.60) | GAATP53L3MBTL1LMNACACNA1G | |
| SCHEMBL6981732 | 0.89 | MEN1 (0.54) | TP53HTTLMNAALDH1A1KMT2A | |
| SCHEMBL6978967 | 0.89 | LMNA (0.53) | TP53LMNAALDH1A1KMT2ACACNA1G | |
| Hydrochloric Acid SCHEMBL5842390 | 0.88 | MEN1 (0.56) | SMN1; SMN2GAATP53HTTLMNA | |
| Hydrochloric Acid SCHEMBL5842876 | 0.88 | KMT2A (0.55) | TP53KDM4ELMNAMAPK1ALDH1A1 | |
| SCHEMBL6985625 | 0.86 | CCR2 (0.48) | SMN1; SMN2LMNAHTR7FPR3FPR2 | |
| SCHEMBL6987557 | 0.86 | HTR1A (0.52) | ALDH1A1HTR7CACNA1G | |
| SCHEMBL6980711 | 0.86 | MAPT (0.57) | SMN1; SMN2TP53L3MBTL1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275647-B1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-11-12 | — | — | EP | disclosed |
| EP-1275647-A1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |