Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.53 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.53 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.53 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.53 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.53 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.53 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.53 |
| ▸ | HTR6 | P50406 | 1/20 | 0.52 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6980375 | 0.90 | LMNA (0.65) | ALDH1A1LMNASMN1; SMN2HTR6SLC40A1 | |
| SCHEMBL6981076 | 0.89 | ALDH1A1 (0.76) | ALDH1A1LMNASMN1; SMN2SLC40A1MEN1 | |
| SCHEMBL2055443 | 0.89 | CYP3A4 (0.61) | ALDH1A1LMNASMN1; SMN2CYP3A4CYP2D6 | |
| SCHEMBL6985862 | 0.85 | ALDH1A1 (0.78) | ALDH1A1LMNASMN1; SMN2SLC40A1NPC1 | |
| SCHEMBL2055424 | 0.83 | CYP3A4 (0.59) | ALDH1A1LMNASMN1; SMN2CYP3A4CYP2D6 | |
| SCHEMBL2055422 | 0.82 | ALPL (0.67) | ALDH1A1LMNASMN1; SMN2CYP3A4MEN1 | |
| SCHEMBL6979083 | 0.82 | SMN1; SMN2 (0.74) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL6978003 | 0.81 | ALDH1A1 (0.76) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL6978649 | 0.81 | ALDH1A1 (1.00) | ALDH1A1LMNASMN1; SMN2SLC40A1NPC1 | |
| SCHEMBL6982196 | 0.81 | ALDH1A1 (0.76) | ALDH1A1LMNASMN1; SMN2NPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163911-B2 | Arylsulfonylaminomethylphosphonic acid derivatives, the preparation thereof and the use thereof as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-04-24 | — | — | US | disclosed |
| US-8163911-B2 | Arylsulfonylaminomethylphosphonic acid derivatives, the preparation thereof and the use thereof as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-04-24 | — | — | US | disclosed |
| US-8163911-B2 | Arylsulfonylaminomethylphosphonic acid derivatives, the preparation thereof and the use thereof as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-04-24 | — | — | US | disclosed |
| US-20100261677-A1 | ARYLSULFONYLAMINOMETHYLPHOSPHONIC ACID DERIVATIVES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-10-14 | — | — | US | disclosed |
| US-20100261677-A1 | ARYLSULFONYLAMINOMETHYLPHOSPHONIC ACID DERIVATIVES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-10-14 | — | — | US | disclosed |
| US-20100261677-A1 | ARYLSULFONYLAMINOMETHYLPHOSPHONIC ACID DERIVATIVES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-10-14 | — | — | US | disclosed |
| WO-2009030715-A1 | ARYLSULFONYLAMINOMETHYLPHOSPHONIC ACID DERIVATIVES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-03-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261677-A1 | ARYLSULFONYLAMINOMETHYLPHOSPHONIC ACID DERIVATIVES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS | ARSA, SULT2A1, PMM2 | ALDH1A1 468/4885LMNA 2804/4885SMN1; SMN2 2062/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.