Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.56 |
| ▸ | PGR | P06401 | 9/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.54 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.54 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.51 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2055421 | 0.90 | ALDH1A1 (0.68) | LMNAALDH1A1SMN1; SMN2SLC40A1PFKFB3 | |
| SCHEMBL6981076 | 0.87 | ALDH1A1 (0.76) | LMNAALDH1A1SMN1; SMN2SLC40A1MAPT | |
| SCHEMBL6985862 | 0.85 | ALDH1A1 (0.78) | LMNAALDH1A1SMN1; SMN2SLC40A1PKM | |
| SCHEMBL6980648 | 0.85 | LMNA (0.65) | LMNAALDH1A1SMN1; SMN2SLC40A1PKM | |
| SCHEMBL6979083 | 0.83 | SMN1; SMN2 (0.74) | LMNAALDH1A1SMN1; SMN2PKMPFKFB3 | |
| SCHEMBL5377995 | 0.81 | ALPL (0.72) | LMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6982196 | 0.79 | ALDH1A1 (0.76) | LMNAALDH1A1SMN1; SMN2PFKFB3MAPT | |
| SCHEMBL2055443 | 0.79 | CYP3A4 (0.61) | LMNAALDH1A1SMN1; SMN2SLC40A1PGR | |
| SCHEMBL6978649 | 0.79 | ALDH1A1 (1.00) | LMNAALDH1A1SMN1; SMN2SLC40A1MAPT | |
| SCHEMBL6978003 | 0.79 | ALDH1A1 (0.76) | LMNAALDH1A1SMN1; SMN2PFKFB3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0991624-B1 | PHENYLALKYL DERIVATIVES WITH THROMBIN-INHIBITING EFFECT | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-11-19 | — | — | EP | disclosed |
| US-6300342-B1 | FOR THERAPY OR INHIBITING THROMBUS FORMATION; FOR THERAPY OF FIBRIN-DEPENDENT INFLAMMATORY CONDITION | BOEHRINGER INGELHEIM PHARM KG (DE) | 2001-10-09 | — | — | US | disclosed |
| EP-0991624-A1 | PHENYLALKYL DERIVATIVES WITH THROMBIN-INHIBITING EFFECT | Boehringer Ingelheim Pharma KG (DE) | 2000-04-12 | — | — | EP | disclosed |
| WO-1999000371-A1 | PHENYLALKYL DERIVATIVES WITH THROMBIN-INHIBITING EFFECT | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-01-07 | — | — | WO | disclosed |