Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.53 |
| ▸ | HTR1A | P08908 | 12/20 | 0.49 |
| ▸ | DRD2 | P14416 | 8/20 | 0.49 |
| ▸ | HTR2A | P28223 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8309830 | 0.82 | LMNA (0.40) | KDM4ELMNAALOX15DRD2HTR2A | |
| SCHEMBL6985174 | 0.81 | HTR6 (0.39) | DRD2HTR6 | |
| Hydrochloric Acid SCHEMBL6986239 | 0.79 | ADRA1D (0.46) | KDM4ESLC6A4POLB | |
| Hydrochloric Acid SCHEMBL6982794 | 0.76 | KMT2A (0.35) | LMNAALOX15DRD2 | |
| SCHEMBL3936672 | 0.76 | HTR1A (0.46) | KDM4EHTR1ASIGMAR1 | |
| SCHEMBL6981092 | 0.75 | DRD3 (0.34) | LMNAALOX15DRD2 | |
| SCHEMBL6984897 | 0.72 | DRD3 (0.38) | KDM4EHTR1AHTR2AHTT | |
| SCHEMBL6986313 | 0.72 | KDM4E (0.53) | KDM4ELMNAALOX15HTR1ADRD2 | |
| SCHEMBL11315106 | 0.71 | KDM4E (0.81) | KDM4ELMNAALOX15HTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL11313113 | 0.71 | KDM4E (0.81) | KDM4ELMNAALOX15HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923575-B1 | CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-03-12 | — | — | EP | disclosed |
| US-6172085-B1 | CENTRAL NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-01-09 | — | — | US | disclosed |