Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 2/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | GRK5 | P34947 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986773 | 1.00 | LMNA (0.42) | LMNATMEM97SIGMAR1AKT2PDPK1 | |
| SCHEMBL6985636 | 0.91 | ROCK2 (0.42) | TMEM97SIGMAR1AKT2PDPK1PDK1 | |
| SCHEMBL6985634 | 0.91 | ROCK2 (0.42) | TMEM97SIGMAR1AKT2PDPK1PDK1 | |
| SCHEMBL6978475 | 0.90 | MEN1 (0.40) | BCHEROCK2SMN1; SMN2PAK4CYP3A4 | |
| SCHEMBL6978482 | 0.90 | MEN1 (0.40) | BCHEROCK2SMN1; SMN2PAK4CYP3A4 | |
| SCHEMBL6979734 | 0.88 | L3MBTL1 (0.45) | LMNAPDPK1L3MBTL1GRK5PAX8 | |
| SCHEMBL6979739 | 0.88 | L3MBTL1 (0.45) | LMNAPDPK1L3MBTL1GRK5PAX8 | |
| SCHEMBL6980866 | 0.87 | SIGMAR1 (0.45) | TMEM97SIGMAR1BCHEGRK5 | |
| SCHEMBL6980870 | 0.87 | SIGMAR1 (0.45) | TMEM97SIGMAR1BCHEGRK5 | |
| SCHEMBL6971260 | 0.87 | JAK3 (0.41) | PDPK1BCHEROCK2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071665-B1 | SUBSTITUTED INDOLINONES HAVING AN INHIBITING EFFECT ON KINASES AND CYCLINE/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-10-01 | — | — | EP | disclosed |
| US-6169106-B1 | ANTITUMOUR AGENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-01-02 | — | — | US | disclosed |