Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6989674 | 0.81 | CYP1A2 (0.50) | CYP3A4CYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL6986920 | 0.80 | MEN1 (0.44) | MEN1KMT2ACYP3A4CYP1A2CYP2C9 | |
| SCHEMBL6990394 | 0.79 | NPC1 (0.40) | MEN1KMT2AALDH1A1GAA | |
| SCHEMBL6981005 | 0.77 | POLB (0.42) | MEN1KMT2ACYP3A4CYP1A2CYP2C9 | |
| SCHEMBL6988211 | 0.75 | POLB (0.40) | MEN1KMT2ACYP3A4CYP1A2CYP2C9 | |
| SCHEMBL6983249 | 0.75 | KMT2A (0.44) | MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL6985151 | 0.75 | KMT2A (0.55) | MEN1KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL6991687 | 0.74 | KMT2A (0.42) | MEN1KMT2ACYP3A4CYP1A2ALDH1A1 | |
| SCHEMBL7146201 | 0.72 | LMNA (0.44) | CYP3A4CYP1A2CYP2C9ALDH1A1MAPT | |
| SCHEMBL8059154 | 0.72 | CYP3A4 (0.62) | CYP3A4CYP1A2CYP2C9CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358160-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2003-11-05 | — | — | EP | claimed |
| WO-2002062761-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | claimed |
| EP-1358160-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002062761-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | disclosed |