Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 4/20 | 0.39 |
| ▸ | HTR1B | P28222 | 4/20 | 0.39 |
| ▸ | NOS3 | P29474 | 2/20 | 0.39 |
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HTR1F | P30939 | 1/20 | 0.37 |
| ▸ | CCR2 | P41597 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6991457 | 0.81 | HTR1D (0.46) | HTR1DHTR1BNOS3NOS1CYP2C9 | |
| SCHEMBL6995543 | 0.79 | SLC6A4 (0.42) | HSD11B1HTR1AMTNR1AMTNR1B | |
| SCHEMBL5351948 | 0.76 | MTNR1A (0.62) | HSD11B1HTR1AMTNR1AMTNR1BCCR2 | |
| SCHEMBL21381780 | 0.72 | KDM4E (0.43) | HTR1DHTR1BALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL4055416 | 0.72 | ALDH1A1 (0.71) | ALDH1A1HSD11B1KDM4EBRD4POLB | |
| SCHEMBL21384720 | 0.69 | KDM4E (0.47) | HTR1DHTR1BALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL4051581 | 0.69 | DRD2 (0.64) | HTR1DHTR1BALDH1A1HSD11B1KDM4E | |
| SCHEMBL21381886 | 0.68 | OPRM1 (0.47) | HTR1DHTR1BNOS3NOS1ALDH1A1 | |
| SCHEMBL7444873 | 0.67 | HSD11B1 (0.56) | HTR1DHTR1BALDH1A1HSD11B1HTR1A | |
| SCHEMBL4056419 | 0.67 | HSD11B1 (0.54) | HTR1DALDH1A1HSD11B1KDM4EBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1330453-A1 | INDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | Almirall Prodesfarma, S.A. (ES) | 2003-07-30 | — | — | EP | disclosed |
| WO-2002036589-A1 | INDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | ALMIRALL PRODESFARMA S.A. (ES) | 2002-05-10 | — | — | WO | disclosed |