Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 13/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.32 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.31 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6383837 | 0.80 | ROCK2 (0.38) | SLC6A3 | |
| SCHEMBL6992764 | 0.78 | HPGD (0.39) | SLC6A3LMNATAOK1TAOK3 | |
| SCHEMBL6996937 | 0.76 | TP53 (0.40) | SLC6A3LMNA | |
| SCHEMBL6986470 | 0.75 | HPGD (0.38) | SLC6A3LMNA | |
| SCHEMBL7144829 | 0.73 | TRPV1 (0.42) | TAOK1TAOK3 | |
| SCHEMBL6300344 | 0.73 | EPHX1 (0.33) | — | |
| SCHEMBL6294295 | 0.70 | CTSL (0.40) | — | |
| SCHEMBL6699255 | 0.70 | CTSL (0.40) | — | |
| SCHEMBL6695685 | 0.70 | CTSB (0.45) | — | |
| SCHEMBL6991868 | 0.69 | CTSL (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358176-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002057246-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |