Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.44 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6989317 | 0.93 | SMN1; SMN2 (0.47) | SMN1; SMN2USP2POLBLTB4RLTB4R2 | |
| SCHEMBL6986947 | 0.90 | LPAR1 (0.51) | SMN1; SMN2MRGPRX4TP53PKMNFKB1 | |
| SCHEMBL6986949 | 0.83 | SLC2A1 (0.48) | POLBLPAR1LPAR5PTGDR2 | |
| SCHEMBL6239722 | 0.80 | KDM5B (0.49) | RXRARXRBLPAR1KDM5BKDM4E | |
| SCHEMBL6990109 | 0.80 | LPAR1 (0.53) | SMN1; SMN2MRGPRX4TP53PKMNFKB1 | |
| SCHEMBL6985928 | 0.78 | KDM5B (0.49) | KDM5BKDM4EKDM6BTET3KDM4A | |
| SCHEMBL6993029 | 0.78 | ALDH1A1 (0.48) | SMN1; SMN2MRGPRX4TP53CYP2D6CYP3A4 | |
| SCHEMBL6989792 | 0.77 | MEN1 (0.45) | TP53USP2LPAR1KDM5BKDM4E | |
| SCHEMBL3854386 | 0.77 | KDM5B (0.57) | TP53KDM5BKDM4EKDM6BTET3 | |
| SCHEMBL6985000 | 0.77 | KDM4C (0.50) | LPAR1KDM5BKDM4EKDM6BTET3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362033-A1 | PYRIDINE MATRIX METALLOPROTEINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2003-11-19 | — | — | EP | claimed |
| WO-2002064568-A1 | PYRIDINE MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-08-22 | — | — | WO | claimed |