Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.43 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6989313 | 0.93 | SMN1; SMN2 (0.47) | SMN1; SMN2NPC1LMNARAB9ACYP2D6 | |
| SCHEMBL6986949 | 0.90 | SLC2A1 (0.48) | POLBPTGDR2CHRM2CHRM1CHRM3 | |
| SCHEMBL6986947 | 0.83 | LPAR1 (0.51) | SMN1; SMN2RAB9APOLBPTGDR2SLC2A1 | |
| SCHEMBL6989792 | 0.81 | MEN1 (0.45) | NPC1LMNARAB9AUSP2CA1 | |
| SCHEMBL6239726 | 0.79 | ALDH1A1 (0.46) | NPC1RAB9ACA1CA2CA9 | |
| SCHEMBL6990114 | 0.79 | LPAR1 (0.49) | SMN1; SMN2LMNACYP3A4CA1CA2 | |
| SCHEMBL6990355 | 0.78 | SLC2A1 (0.61) | SMN1; SMN2POLBSLC2A1SLC2A4 | |
| SCHEMBL5217831 | 0.77 | CA1 (0.62) | SMN1; SMN2NPC1LMNARAB9ACYP2D6 | |
| SCHEMBL6985934 | 0.77 | MAPT (0.43) | SMN1; SMN2NPC1RAB9APOLBMAPT | |
| SCHEMBL6993032 | 0.77 | KMT2A (0.49) | SMN1; SMN2LMNACYP2D6CYP3A4CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362033-A1 | PYRIDINE MATRIX METALLOPROTEINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2003-11-19 | — | — | EP | claimed |
| WO-2002064568-A1 | PYRIDINE MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-08-22 | — | — | WO | claimed |