Sugi Predict

Sugi Predict / Compounds / SCHEMBL6992159

SCHEMBL6992159

SCHEMBL6992159

FC(F)(F)c1cccc(I)c1C(F)(F)F

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HSD11B1 P28845 1/20 0.40
▸ NOTUM Q6P988 1/20 0.39
▸ KDM4E B2RXH2 1/20 0.36
▸ SMN1; SMN2 Q16637 1/20 0.36
▸ HSD17B10 Q99714 1/20 0.36
▸ ALDH1A1 P00352 1/20 0.34
▸ POLB P06746 1/20 0.34
▸ TDP1 Q9NUW8 1/20 0.34
▸ L3MBTL1 Q9Y468 1/20 0.34
▸ AXL P30530 1/20 0.34
▸ KIF11 P52732 1/20 0.34
▸ TAAR1 Q96RJ0 1/20 0.34
▸ PARP1 P09874 1/20 0.34
▸ P2RX7 Q99572 1/20 0.33
▸ CES1 P23141 1/20 0.33
▸ CNR2 P34972 1/20 0.33
▸ IDO1 P14902 2/20 0.32
▸ CA2 P00918 1/20 0.32
▸ PNMT P11086 1/20 0.32
▸ CHRNB2 P17787 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25147648 0.85 NOTUM (0.44) NOTUMALDH1A1
SCHEMBL22140380 0.85 CA2 (0.37) HSD11B1NOTUMKDM4ESMN1; SMN2HSD17B10
SCHEMBL2000756 0.82 HSD11B1 (0.46) HSD11B1KDM4ESMN1; SMN2HSD17B10ALDH1A1
Lithium SCHEMBL5691154 0.79 HSD11B1 (0.44) HSD11B1KDM4ESMN1; SMN2HSD17B10ALDH1A1
SCHEMBL8499174 0.78 KDM4E (0.37) KDM4ESMN1; SMN2HSD17B10ALDH1A1POLB
SCHEMBL11526 0.77 ALDH1A1 (0.43) HSD11B1NOTUMKDM4ESMN1; SMN2HSD17B10
SCHEMBL29673099 0.77 ALDH1A1 (0.43) HSD11B1NOTUMKDM4ESMN1; SMN2HSD17B10
SCHEMBL30364632 0.76 MPL (0.40) HSD11B1NOTUMKDM4ESMN1; SMN2HSD17B10
SCHEMBL26899299 0.76 NOTUM (0.39) NOTUMP2RX7CES1
SCHEMBL12326344 0.76 MPL (0.40) HSD11B1NOTUMKDM4ESMN1; SMN2HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103772480-A High-yield dutasteride preparation method BEIJING VENTUREPHARM BIOTECH CORP 2014-05-07 — — CN claimed
US-6395921-B1 DEPROTINATION, COPPER SALT AND DILUENTS, HYDROLYSIS AND DECARBOXYLATION BAYER AKTIENGESELLSCHAFT (DE) 2002-05-28 — — US claimed
EP-1077208-A2 Process for the preparation of (bis-(trifluormethyl)-phenyl)-acetic acids and their alkyl esters as well as dialkyl esters of (bis-(trifluormethyl)-phenyl)-malonic acid BAYER AG (DE) 2001-02-21 — — EP claimed
EP-0383621-B1 Diphenyldiacetylene derivative TODA KOGYO CORP (JP) 1993-12-08 — — EP claimed
EP-0383621-A1 Diphenyldiacetylene derivative TODA KOGYO CORP. (JP) 1990-08-22 — — EP claimed
JP-2215742-A — — None — — JP disclosed
WO-2023147244-A1 POLYURETHANE ADHESIVE DOW GLOBAL TECHNOLOGIES LLC (US) 2023-08-03 — — WO disclosed
WO-2022086946-A1 POLYURETHANE COMPOSITION DOW GLOBAL TECHNOLOGIES LLC (US) 2022-04-28 — — WO disclosed
EP-3681932-B1 LEWIS ACID POLYMERIZATION CATALYST DOW GLOBAL TECHNOLOGIES LLC (US) 2021-06-09 — — EP disclosed
WO-2019055740-A1 LEWIS ACID POLYMERIZATION CATALYST DOW GLOBAL TECHNOLOGIES LLC (US) 2019-03-21 — — WO disclosed
CN-102286142-B Dibenzofuran and derivatives, preparation method and application thereof NINGBO INST MAT TECH & ENG CAS 2014-09-03 — — CN disclosed
CN-103772480-A High-yield dutasteride preparation method BEIJING VENTUREPHARM BIOTECH CORP 2014-05-07 — — CN disclosed
US-20020042541-A1 Process for producing bis( trifluoromethyl)benzaldehyde CENTRAL GLASS COMPANY, LIMITED (JP) 2002-04-11 — — US disclosed
JP-2001081065-A METHOD FOR PRODUCING [BIS-(TRIFLUOROMETHYL)-PHENYL]- ACETIC ACID, ITS ALKYL ESTER AND DIALKYL BIS-(TRIFLUOROMETHYL)-PHENYL]-MALONATE BAYER AG 2001-03-27 — — JP disclosed
EP-1077208-A2 Process for the preparation of (bis-(trifluormethyl)-phenyl)-acetic acids and their alkyl esters as well as dialkyl esters of (bis-(trifluormethyl)-phenyl)-malonic acid BAYER AG (DE) 2001-02-21 — — EP disclosed
EP-1077208-A2 Process for the preparation of (bis-(trifluormethyl)-phenyl)-acetic acids and their alkyl esters as well as dialkyl esters of (bis-(trifluormethyl)-phenyl)-malonic acid BAYER AG (DE) 2001-02-21 — — EP disclosed
EP-0383621-B1 Diphenyldiacetylene derivative TODA KOGYO CORP (JP) 1993-12-08 — — EP disclosed
US-5196586-A Polydiphenyldiacetylenes TODA KOGYO CORP. (JP) 1993-03-23 — — US disclosed
JP-H02215742-A DIPHENYLDIACETYLENE DERIVATIVE HAVING SOLID-PHASE POLYMERIZABILITY AGENCY OF IND SCIENCE & TECHNOL 1990-08-28 — — JP disclosed
EP-0383621-A1 Diphenyldiacetylene derivative TODA KOGYO CORP. (JP) 1990-08-22 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020042541-A1 Process for producing bis( trifluoromethyl)benzaldehyde BRPF1, PFAS, FLI1 HSD11B1 2541/4885NOTUM 1207/4885KDM4E 2526/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.