Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.37 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7381725 | 0.92 | PDE4A (0.39) | PDE4APDE4BPDE4CPDE4DLPAR1 | |
| SCHEMBL6992446 | 0.88 | LMNA (0.38) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7893458 | 0.82 | RIPK2 (0.46) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7511580 | 0.81 | LMNA (0.42) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7378633 | 0.78 | TSHR (0.49) | PDE4APDE4BPDE4CPDE4DCYP2D6 | |
| SCHEMBL6997649 | 0.77 | LMNA (0.38) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7843449 | 0.77 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7361207 | 0.75 | KMT2A (0.45) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL6997571 | 0.74 | ALDH1A1 (0.38) | LMNAFAAHKMT2AMEN1 | |
| SCHEMBL27481625 | 0.73 | L3MBTL1 (0.34) | LMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973774-B1 | 1,5-DIHYDRO-PYRAZOLO 3,4-D]-PYRIMIDINONE DERIVATIVES | BAYER AG (DE) | 2003-01-22 | — | — | EP | disclosed |
| EP-0973774-A1 | 1,5-DIHYDRO-PYRAZOLO 3,4-D]-PYRIMIDINONE DERIVATIVES | BAYER AG (DE) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998040384-A1 | 1,5-DIHYDRO-PYRAZOLO[3,4-D]-PYRIMIDINONE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 1998-09-17 | — | — | WO | disclosed |