Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | TSPO | P30536 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6998457 | 0.86 | ALDH1A1 (0.50) | SIRT1ALDH1A1HPGDCYP1A2XBP1 | |
| SCHEMBL27459777 | 0.84 | ADRA2A (0.53) | SIRT1ALDH1A1HPGDCYP1A2XBP1 | |
| SCHEMBL27387994 | 0.74 | ALOX15 (0.51) | PTGS2 | |
| SCHEMBL6994825 | 0.69 | ALDH1A1 (0.41) | ALDH1A1HPGDCYP1A2KDM4EHSD17B10 | |
| SCHEMBL27939080 | 0.69 | ALDH1A1 (0.46) | ALDH1A1CYP1A2CYP2C19KDM4EHSD17B10 | |
| SCHEMBL11544126 | 0.68 | ADORA3 (0.45) | CSF1R | |
| SCHEMBL25433849 | 0.68 | ALDH1A1 (0.55) | ALDH1A1HPGDCYP1A2XBP1CYP2C19 | |
| SCHEMBL8296306 | 0.68 | PRSS1 (0.55) | SIRT1ALDH1A1HPGDCYP1A2XBP1 | |
| SCHEMBL12496609 | 0.68 | ALDH1A1 (0.66) | SIRT1ALDH1A1HPGDCYP1A2XBP1 | |
| SCHEMBL27366263 | 0.68 | ALDH1A1 (0.52) | SIRT1ALDH1A1HPGDKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003724-B1 | SUBSTITUTED QUINOLINE DERIVATIVES WITH ANTIVIRAL ACTION | AVENTIS PHARMA GMBH (DE) | 2003-02-12 | — | — | EP | disclosed |
| US-6114349-A | Substituted quinoline derivatives with antiviral action | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-09-05 | — | — | US | disclosed |
| EP-1003724-A1 | SUBSTITUTED QUINOLINE DERIVATIVES WITH ANTIVIRAL ACTION | Aventis Pharma Deutschland GmbH (DE) | 2000-05-31 | — | — | EP | disclosed |
| WO-1997037977-A1 | SUBSTITUTED QUINOLINE DERIVATIVES WITH ANTIVIRAL ACTION | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-10-16 | — | — | WO | disclosed |