Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6997571 | 0.82 | ALDH1A1 (0.38) | TSHRPOLBMAOB | |
| SCHEMBL7893458 | 0.81 | RIPK2 (0.46) | TSHRCYP2D6PDE4APDE4BPDE4C | |
| SCHEMBL27481625 | 0.81 | L3MBTL1 (0.34) | TSHRSIGMAR1MAOB | |
| SCHEMBL7381725 | 0.79 | PDE4A (0.39) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6996007 | 0.78 | PDE4A (0.41) | CYP2D6PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7850685 | 0.78 | NOS3 (0.40) | POLBCYP2D6SIGMAR1NOS3NOS1 | |
| SCHEMBL7361207 | 0.70 | KMT2A (0.45) | TSHRPOLBCYP2D6PDE4APDE4B | |
| SCHEMBL7843449 | 0.69 | PDE4A (0.40) | CYP2D6PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7511580 | 0.69 | LMNA (0.42) | CYP2D6PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27468086 | 0.69 | GAA (0.52) | TSHRPOLBDHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973774-A1 | 1,5-DIHYDRO-PYRAZOLO 3,4-D]-PYRIMIDINONE DERIVATIVES | BAYER AG (DE) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998040384-A1 | 1,5-DIHYDRO-PYRAZOLO[3,4-D]-PYRIMIDINONE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 1998-09-17 | — | — | WO | disclosed |