Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.55 |
| ▸ | CFTR | P13569 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.53 |
| ▸ | HPGD | P15428 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
| ▸ | FADS1 | O60427 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6366964 | 0.82 | ALDH1A1 (0.53) | ALDH1A1HSD17B10CFTRKDM4EHPGD | |
| SCHEMBL5574637 | 0.82 | FADS1 (0.54) | ALDH1A1HSD17B10CFTRKDM4EHPGD | |
| SCHEMBL8477209 | 0.80 | SIRT2 (0.47) | ALDH1A1HSD17B10KDM4EHPGDPOLB | |
| SCHEMBL375579 | 0.79 | ALDH1A1 (0.59) | ALDH1A1HSD17B10CFTRKDM4EHPGD | |
| SCHEMBL9921278 | 0.79 | KDM4E (0.60) | ALDH1A1HSD17B10CFTRKDM4EHPGD | |
| Acetic Acid SCHEMBL28650473 | 0.78 | KDM4E (0.56) | ALDH1A1HSD17B10CFTRKDM4EHPGD | |
| SCHEMBL8634908 | 0.78 | RAB9A (0.50) | ALDH1A1HSD17B10CFTRKDM4EHPGD | |
| SCHEMBL5807531 | 0.78 | MAPT (0.60) | ALDH1A1HSD17B10CFTRKDM4ERAB9A | |
| SCHEMBL28193055 | 0.78 | ALDH1A1 (0.48) | ALDH1A1HSD17B10CFTRKDM4EHPGD | |
| SCHEMBL15361168 | 0.78 | SMN1; SMN2 (0.68) | ALDH1A1HSD17B10KDM4EHPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294707-A2 | THIOPHENE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2003-03-26 | — | — | EP | claimed |
| WO-2001098290-A2 | THIOPHENE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA S.P.A. (IT) | 2001-12-27 | — | — | WO | claimed |
| US-6414013-B1 | KINASE INHIBITORS; ANTICANCER AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2002-07-02 | — | — | US | disclosed |