Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | MAOB | P27338 | 14/20 | 0.58 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7004914 | 0.77 | NPC1 (0.61) | MAPTSMN1; SMN2NPC1RAB9AMAOB | |
| SCHEMBL7674903 | 0.76 | GAA (0.61) | MAPTNPC1RAB9AMAOBLMNA | |
| SCHEMBL8288650 | 0.74 | ALDH1A1 (0.68) | MAPTSMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL30643084 | 0.72 | MAOB (0.72) | MAPTSMN1; SMN2NPC1RAB9AMAOB | |
| SCHEMBL4974849 | 0.72 | MAOB (0.72) | MAPTSMN1; SMN2NPC1RAB9AMAOB | |
| SCHEMBL4973439 | 0.72 | MAOB (1.00) | MAOBADORA2BMAOA | |
| SCHEMBL11875283 | 0.72 | MAOB (0.69) | MAPTSMN1; SMN2NPC1RAB9AMAOB | |
| SCHEMBL5794137 | 0.72 | ALDH1A1 (0.78) | MAPTSMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL7003777 | 0.71 | ALDH1A1 (0.62) | MAPTSMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL11877461 | 0.71 | MAOB (0.63) | MAOBADORA2BMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294707-A2 | THIOPHENE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2003-03-26 | — | — | EP | claimed |
| US-6414013-B1 | KINASE INHIBITORS; ANTICANCER AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2002-07-02 | — | — | US | claimed |
| WO-2001098290-A2 | THIOPHENE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA S.P.A. (IT) | 2001-12-27 | — | — | WO | claimed |