Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | BCL2L11 | O43521 | 2/20 | 0.33 |
| ▸ | BCL2 | P10415 | 2/20 | 0.33 |
| ▸ | BID | P55957 | 2/20 | 0.33 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PRKCB | P05771 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL7012152 | 0.98 | F2RL3 (0.43) | F2RL3TP53CAMK2DCA12CA1 | |
| SCHEMBL7005339 | 0.74 | CAMK2D (0.55) | CAMK2DPRKCBPRKCAPRKCHPRKCE | |
| Acetic Acid SCHEMBL7007558 | 0.73 | CAMK2D (0.53) | CAMK2DPRKCBPRKCAPRKCHPRKCE | |
| SCHEMBL7005879 | 0.71 | PIM1 (0.48) | TP53CAMK2DSIRT2MAPTPRKCB | |
| SCHEMBL7005313 | 0.69 | PKM (0.40) | ALDH1A1MAPTPRKCBPRKCAMAT2A | |
| SCHEMBL6974638 | 0.69 | PRKCB (0.40) | CAMK2DSIRT2PDE4APDE4BPDE4C | |
| Acetic Acid SCHEMBL7011660 | 0.69 | CAMK2D (0.46) | TP53CAMK2DSIRT2MAPTPRKCB | |
| Acetic Acid SCHEMBL6983601 | 0.68 | CAMK2D (0.52) | CAMK2DPRKCBPRKCAPRKCHPRKCE | |
| Trifluoroacetic Acid SCHEMBL6981001 | 0.67 | TPSAB1 (0.41) | CAMK2DCA12CA1CA2CA9 | |
| SCHEMBL6980982 | 0.67 | PRKACA (0.39) | TP53CAMK2DSIRT2PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042317-B1 | Indole derivatives as PKC-inhiboitors | ASTRAZENECA AB (SE) | 2003-05-14 | — | — | EP | claimed |
| US-6337342-B1 | ARYLIMIDAZOLONE DERIVATIVES | ASTRAZENECA AB (SE) | 2002-01-08 | — | — | US | claimed |
| EP-1042317-B1 | Indole derivatives as PKC-inhiboitors | ASTRAZENECA AB (SE) | 2003-05-14 | — | — | EP | disclosed |